This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wigley, P. Articles by Barrow, P. Search for Related Content PubMed PubMed Citation Articles by Wigley, P. Articles by Barrow, P.

 Previous Article  |  Next Article 

Infection and Immunity, February 2006, p. 1425-1430, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1425-1430.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Macrophages Isolated from Chickens Genetically Resistant or Susceptible to Systemic Salmonellosis Show Magnitudinal and Temporal Differential Expression of Cytokines and Chemokines following Salmonella enterica Challenge

Paul Wigley,^* Scott Hulme, Lisa Rothwell, Nat Bumstead, Pete Kaiser, and Paul Barrow^,

Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom

Received 4 August 2005/ Returned for modification 12 October 2005/ Accepted 30 November 2005

Macrophages from inbred chickens that are resistant to salmonellosis show greater and more rapid expression of proinflammatory chemokines and cytokines, including the key Th1-inducing cytokine interleukin-18, upon Salmonella challenge than those from susceptible birds. This suggests the possibility that salmonellosis resistant-line macrophages signal more effectively and rapidly and are more able to induce protective Th1 adaptive responses.

Sadly, Nat Bumstead passed away during this study. We fondly dedicate this paper to his memory.

Editor: F. C. Fang

Present address: School of Veterinary Medicine and Science, The University of Nottingham, South Bonington, Loughborough, Leicestershire LE12 5RD, United Kingdom.

This article has been cited by other articles:

• Jeong, J.-H., Song, M., Park, S.-I., Cho, K.-O., Rhee, J. H., Choy, H. E. (2008). Salmonella enterica Serovar Gallinarum Requires ppGpp for Internalization and Survival in Animal Cells. J. Bacteriol. 190: 6340-6350 [Abstract] [Full Text]  
• Sun, S. F., Pan, Q. Z., Hui, X., Zhang, B. L., Wu, H. M., Li, H., Xu, W., Zhang, Q., Li, J. Y., Deng, X. M., Chen, J. W., Lian, Z. X., Li, N. (2008). Stronger In Vitro Phagocytosis by Monocytes-Macrophages Is Indicative of Greater Pathogen Clearance and Antibody Levels In Vivo. Poult. Sci. 87: 1725-1733 [Abstract] [Full Text]