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Infection and Immunity, January 2006, p. 390-393, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.390-393.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Complement and Fc Function Are Required for Optimal Antibody Prophylaxis against Pneumocystis carinii Pneumonia

Jesse Wells,1 Constantine G. Haidaris,1 Terry W. Wright,1,2 and Francis Gigliotti1,2*

Departments of Microbiology and Immunology,1 Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 146422

Received 14 September 2005/ Returned for modification 10 October 2005/ Accepted 24 October 2005

Pneumocystis carinii is an opportunistic fungal pathogen that causes P. carinii pneumonia (PCP) in the immunocompromised host. We investigated the role of antibody Fc-mediated function in passive prophylaxis against the development of PCP in SCID mice. By comparison of anti-mouse P. carinii immunoglobulin G1 monoclonal antibody (MAb) 4F11(G1) and its F(ab')2 derivative in an intranasal immunoprophylaxis model, we determined that Fc-mediated function is required for maximum effect of this antibody. Comparison of efficacy of antibody prophylaxis in SCID mice depleted of complement to that in nondepleted mice demonstrated that complement fixation by MAb 4F11(G1) is also necessary for optimal effect of passively administered antibody, although residual protection was observed in complement-depleted SCID mice. The necessity of complement for optimal PCP prophylaxis by MAb 4F11(G1) suggests that complement may play a role in antibody-mediated protection against development of PCP.

* Corresponding author. Mailing address: University of Rochester School of Medicine and Dentistry, Department of Pediatrics, Box 690, 601 Elmwood Ave., Rochester, NY 14642. Phone: (585) 275-5944. Fax: (585) 273-1104. E-mail: Francis_Gigliotti{at}urmc.rochester.edu.

Editor: A. Casadevall

Infection and Immunity, January 2006, p. 390-393, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.390-393.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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