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Infection and Immunity, September 2005, p. 6191-6193, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6191-6193.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Anti-Candida albicans Vaccine Composed of the Recombinant N Terminus of Als1p Reduces Fungal Burden and Improves Survival in Both Immunocompetent and Immunocompromised Mice

Division of Infectious Diseases, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, Torrance, California,¹ The David Geffen School of Medicine at UCLA, Los Angeles, California²

Received 14 March 2005/ Accepted 11 April 2005

We have previously shown that intraperitoneal vaccination with the recombinant N terminus of Als1p (rAls1p-N) modestly improves survival during murine disseminated candidiasis. We now report marked efficacy with subcutaneous rAls1p-N vaccination. Efficacy is retained in neutropenic and corticosteroid-treated mice. The rAls1p-N vaccine is a promising candidate for the prevention of invasive candidiasis.

Editor: T. R. Kozel

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