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Infection and Immunity, August 2005, p. 5249-5251, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5249-5251.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Prolonged Survival of a Murine Model of Cerebral Malaria by Kynurenine Pathway Inhibition

Catherine J. Clark,1* Gillian M. Mackay,1 George A. Smythe,2 Sonia Bustamante,2 Trevor W. Stone,1 and R. Stephen Phillips1

Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom,1 Biomedical Mass Spectrometry Facility, University of New South Wales, Sydney, New South Wales 2052, Australia2

Received 9 November 2004/ Returned for modification 9 February 2005/ Accepted 3 March 2005

C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hydroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.

* Corresponding author. Mailing address: Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom. Phone: 44 (0)141 330 2407. Fax: 44 (0)141 330 4600. E-mail: cc30r{at}clinmed.gla.ac.uk.

Editor: J. L. Flynn

Infection and Immunity, August 2005, p. 5249-5251, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5249-5251.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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