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Infection and Immunity, March 2005, p. 1868-1872, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1868-1872.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Production of a Proteolytically Active Protein, Chlamydial Protease/Proteasome-Like Activity Factor, by Five Different Chlamydia Species

Feng Dong,1 Youmin Zhong,1 Bernard Arulanandam,2 and Guangming Zhong1*

Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio,1 Department of Biology, University of Texas at San Antonio, San Antonio, Texas2

Received 25 August 2004/ Returned for modification 15 October 2004/ Accepted 19 October 2004

We have previously identified a chlamydial protein, chlamydial protease/proteasome-like activity factor (CPAF), for degrading host transcription factors in cells infected with the human chlamydial species Chlamydia trachomatis or Chlamydia pneumoniae. We now report that functional CPAF was also produced during infection with the species Chlamydia muridarum, Chlamydia psittaci, and Chlamydia caviae, which primarily infect nonhuman hosts.


* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229. Phone: (210) 567-1169. Fax: (210) 567-0293. E-mail: Zhongg{at}UTHSCSA.EDU.

Editor: F. C. Fang


Infection and Immunity, March 2005, p. 1868-1872, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1868-1872.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




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