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Infection and Immunity, March 2005, p. 1861-1864, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1861-1864.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Degradation of the Proapoptotic Proteins Bik, Puma, and Bim with Bcl-2 Domain 3 Homology in Chlamydia trachomatis-Infected Cells

Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas,¹ Department of Microbiology, Nanhua University, Hengyang, Hunan, China²

Received 17 September 2004/ Returned for modification 21 September 2004/ Accepted 4 November 2004

We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and the inhibition of Bax and Bak activation. We now report that C. trachomatis infection leads to degradation of Bik, Puma, and Bim, three upstream proapoptotic BH3-only proteins of the Bcl-2 family that can transmit death signals to mitochondria by inhibiting the Bcl-2 antiapoptotic proteins and/or activating the Bcl-2 proapoptotic members, such as Bax and Bak. This observation has provided new information on the chlamydial antiapoptosis mechanisms.

Editor: D. L. Burns

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