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Infection and Immunity, January 2005, p. 627-631, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.627-631.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Vaccination with Purified Dr Fimbriae Reduces Mortality Associated with Chronic Urinary Tract Infection Due to Escherichia coli Bearing Dr Adhesin

Pawel Goluszko,1* Elzbieta Goluszko,2,{dagger} Bogdan Nowicki,1,2 Stella Nowicki,1,2 Vsevolod Popov,3 and Hui-Qun Wang4

Departments of Obstetrics & Gynecology,1 Microbiology & Immunology,2 Pathology,3 Research Histopathology Core, University of Texas Medical Branch, Galveston, Texas4

Received 12 February 2004/ Returned for modification 13 May 2004/ Accepted 22 September 2004

The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

* Corresponding author. Mailing address: University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1062. Phone: (409) 772-2221, Fax: (409) 747-0475. E-mail: pgoluszk{at}utmb.edu.

Editor: V. J. DiRita

{dagger} Present address: Department of Surgery, University of Texas Medical Branch, Galveston, Texas.

Infection and Immunity, January 2005, p. 627-631, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.627-631.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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Copyright © 2005 by the American Society for Microbiology. All rights reserved.