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Infection and Immunity, October 2003, p. 6045-6048, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6045-6048.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin-15 as an Immune Adjuvant To Increase the Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin Vaccination

Molecular Microbiology Group, Center of Molecular Biosciences, University of the Ryukyus, Okinawa 903-0213,¹ Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582 ,² Department of Molecular Pathology, the Research Institute of Tuberculosis, Kiyose 204-0022, Japan³

Received 17 March 2003/ Returned for modification 7 May 2003/ Accepted 30 June 2003

Interleukin-15 (IL-15) transgenic mice which had been inoculated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) 24 weeks previously showed resistance against airborne infection with Mycobacterium tuberculosis H37Rv accompanied by an increased CD8⁺-Tc1-cell response. IL-15 may be used as an immune adjuvant given with BCG vaccination to enhance its biologic efficacy.

Editor: J. D. Clements

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