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Infection and Immunity, June 2001, p. 3800-3808, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.3800-3808.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Helicobacter pylori Lipopolysaccharides Preferentially Induce CXC Chemokine Production in Human Monocytes

M. Innocenti, A.-M. Svennerholm, and M. Quiding-Järbrink*

Department of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden

Received 2 November 2000/Returned for modification 9 February 2001/Accepted 5 March 2001

Helicobacter pylori infection can cause duodenal ulcers and may also induce gastric adenocarcinoma. The bacteria colonize the gastric mucosa and areas of gastric metaplasia in the duodenum for decades, resulting in active chronic inflammation in the infected areas. A characteristic feature of the infection is the ongoing recruitment of neutrophils to the infected sites. To evaluate the role of H. pylori lipopolysaccharides (LPS) in the recruitment of leukocytes to the gastric mucosa, we have examined the cytokine and chemokine production from human monocytes stimulated with LPS isolated from different H. pylori strains, as well as from several other gram-negative bacteria. Our results show that H. pylori LPS induce a large production of neutrophil-recruiting CXC chemokines (interleukin-8 and growth-related oncogene alpha) from purified human monocytes, to almost the same extent as Escherichia coli LPS. However, and in agreement with previous studies, H. pylori LPS was much less potent in inducing production of proinflammatory cytokines by purified human monocytes and was also a weak inducer of the CC chemokine RANTES. There was no difference between LPS preparations from different H. pylori strains in their ability to induce cytokines and chemokines. The preferential production of CXC chemokines after stimulation with H. pylori LPS indicates an important contribution of this molecule in maintaining neutrophil recruitment during the infection, irrespective of the infecting strain.

* Corresponding author. Mailing address: Dept. of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10 A, S-413 46 Göteborg, Sweden. Phone: 46 31 42 44 92. Fax: 46 31 82 01 60. E-mail: marianne.quiding{at}microbio.gu.se.

Infection and Immunity, June 2001, p. 3800-3808, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.3800-3808.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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