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Infection and Immunity, February 2001, p. 1175-1177, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1175-1177.2001

Macrophage-Derived Cell Lines Do Not Express Proinflammatory Cytokines after Exposure to Bacillus anthracis Lethal Toxin

James L. Erwin,1,2 Luis M. DaSilva,3 Sina Bavari,3 Stephen F. Little,4 Arthur M. Friedlander,1 and Tran C. Chanh1,2,*

Headquarters,1 Division of Virology,2 Division of Toxinology,3 and Division of Bacteriology,4 United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011

Received 20 July 2000/Returned for modification 8 September 2000/Accepted 7 November 2000

We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of LT and involves inhibition of transcription of cytokine messenger RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory response.

* Corresponding author. Mailing address: U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21702-5011. Phone: (301) 619-4795. Fax: (301) 619-4268. E-mail: Tran.Chanh{at}DET.AMEDD.army.mil.

Infection and Immunity, February 2001, p. 1175-1177, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1175-1177.2001


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