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Infection and Immunity, January 2001, p. 584-588, Vol. 69, No. 1
EPI INSERM 9933, Epidémiologie de la
Résistance aux Anti-infectieux, Groupe Hospitalier Bichat-Claude
Bernard, Assistance Publique Hôpitaux de Paris 75018 Paris,1 and Centre d'Etudes sur le
Polymorphisme des Microorganismes (CEPM), UMR CNRS/IRD 9926, IRD,
Montpellier,2 France
Received 18 July 2000/Returned for modification 12 September
2000/Accepted 23 October 2000
Random amplified polymorphic DNA typing was used to study the
genetic diversity of Pseudomonas aeruginosa strains from
(i) ventilated patients with nosocomial pneumonia who were hospitalized in intensive care units, (ii) cases of bacteremia in cancer patients with severe neutropenia, and (iii) rivers and swimming pools. Genetic
diversity was determined by three phylogenetic methods and by
statistical analysis of population genetics. The population studied
undergoes epidemic clonality with a high rate of genetic recombination.
P. aeruginosa bacteremia and pneumonia are not caused by
specific clones within this species.
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.1.584-588.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Genetic Diversity of Pseudomonas
aeruginosa Strains Isolated from Ventilated Patients with
Nosocomial Pneumonia, Cancer Patients with Bacteremia, and
Environmental Water
for the
P. aeruginosa Study Group
*
Corresponding author. Mailing address: Laboratoire de
Bactériologie, Groupe Hospitalier Bichat-Claude Bernard, 46 rue
Henri Huchard, 75877 Paris Cedex 18, France. Phone: (33) 1 40 25 85 00. Fax: (33) 1 40 25 85 81. E-mail:
antoine.andremont{at}bch.ap-hop-paris.fr.
Other members of The P. aeruginosa Study Group include
Marie-Hélène Nicolas-Chanoine, Hervé Richet, Jean
Pierre Flandrois, Brigitte Mulin, Francis Megraud, Philippe Lagrange,
Elisabeth Chachaty, Cyrille Tancrède, Mylène Bernos, Jean
Chastre, Jean Louis Trouillet, Claude Gibert, Michel Wolff, Bernard
Regnier, and François Vachon.
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