IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DeBord, K. L.
Right arrow Articles by Schneewind, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DeBord, K. L.
Right arrow Articles by Schneewind, O.

 Previous Article  |  Next Article 

Infection and Immunity, August 2006, p. 4910-4914, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.01860-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Immunogenicity and Protective Immunity against Bubonic Plague and Pneumonic Plague by Immunization of Mice with the Recombinant V10 Antigen, a Variant of LcrV

Kristin L. DeBord,1 Deborah M. Anderson,1 Melanie M. Marketon,1 Katie A. Overheim,1 R. William DePaolo,2 Nancy A. Ciletti,1 Bana Jabri,2 and Olaf Schneewind1*

Department of Microbiology,1 Department of Pathology, University of Chicago, Chicago, Illinois 606372

Received 14 November 2005/ Returned for modification 27 January 2006/ Accepted 24 April 2006

In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.

* Corresponding author. Mailing address: Department of Microbiology, University of Chicago, 920 E. 58th Street, Chicago, IL 60637. Phone: (773) 834-9060. Fax: (773) 834-8150. E-mail: oschnee{at}bsd.uchicago.edu.

Editor: V. J. DiRita

Infection and Immunity, August 2006, p. 4910-4914, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.01860-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2006 by the American Society for Microbiology. All rights reserved.