IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pierrot, C.
Right arrow Articles by Khalife, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pierrot, C.
Right arrow Articles by Khalife, J.

 Previous Article  |  Next Article 

Infection and Immunity, June 2006, p. 3347-3354, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.01724-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification of a Novel Antigen of Schistosoma mansoni Shared with Plasmodium falciparum and Evaluation of Different Cross-Reactive Antibody Subclasses Induced by Human Schistosomiasis and Malaria

Christine Pierrot,1 Shona Wilson,2 Hélène Lallet,1 Sophia Lafitte,1 Frances M. Jones,2 Wassim Daher,1 Monique Capron,1 David W. Dunne,2* and Jamal Khalife1*

Unité Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France,1 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom2

Received 21 October 2005/ Returned for modification 17 January 2006/ Accepted 7 March 2006

Plasmodium falciparum and Schistosoma mansoni are often found in human coinfections, and cross-reactive antibodies to different components of the two parasites have been detected. In this work, we identified a cross-reactive S. mansoni gene product, referred to as SmLRR, that seems to belong to the leucine-rich repeat protein family. Comparative analysis of SmLRR revealed 57% similarity with a putative gene product encoded in the P. falciparum genome. Antibodies to SmLRR were found in experimental infections and in both S. mansoni- and P. falciparum-infected individuals. Correlative analysis of human anti-SmLRR responses in Kenya and Uganda suggested that malaria and schistosomiasis drive the immunoglobulin G3 (IgG3) and IgG4 isotypes, respectively, against SmLRR, suggesting that there is differential regulation of cross-reactive isotypes depending on the infection. In addition, the levels of anti-SmLRR IgG4, but not the levels of IgG3, correlated positively with the intensity of S. mansoni infection.

* Corresponding author. Mailing address for Jamal Khalife: Unité Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France. Phone: (33) 320877968. Fax: (33) 320877888. E-mail: jamal.khalife{at}pasteur-lille.fr. Mailing address for David W. Dunne: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom. Phone: (44) 1223333336. Fax: (44) 1223333741. E-mail: dd{at}mole.bio.cam.ac.uk.

Editor: J. F. Urban, Jr.

Infection and Immunity, June 2006, p. 3347-3354, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.01724-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2006 by the American Society for Microbiology. All rights reserved.