This Article Full Text Full Text (PDF) Other Versions of this Article: IAI.00071-06v1 74/12/7010    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Skaleric, U. Articles by Wahl, S. M. Search for Related Content PubMed PubMed Citation Articles by Skaleric, U. Articles by Wahl, S. M.

 Previous Article  |  Next Article 

Infection and Immunity, December 2006, p. 7010-7013, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00071-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease

Department of Oral Medicine & Periodontology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia,¹ Oral Infection & Immunity Branch, NIDCR, NIH, Bethesda, Maryland,² Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia³

Received 13 January 2006/ Returned for modification 27 February 2006/ Accepted 23 September 2006

Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.

Published ahead of print on 2 October 2006.

Editor: F. C. Fang

This article has been cited by other articles:

• Ghosh, A., Park, J. Y., Fenno, C., Kapila, Y. L. (2008). Porphyromonas gingivalis, Gamma Interferon, and a Proapoptotic Fibronectin Matrix Form a Synergistic Trio That Induces c-Jun N-Terminal Kinase 1-Mediated Nitric Oxide Generation and Cell Death. Infect. Immun. 76: 5514-5523 [Abstract] [Full Text]