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Previous Article | Next Article 
Clinical and Diagnostic Laboratory Immunology, September 2001, p. 867-870, Vol. 8, No. 5
1071-412X/01/$04.00+0 DOI: 10.1128/CDLI.8.5.867-870.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
GUEST COMMENTARY
Reciprocal Interaction of Human
Immunodeficiency Virus and Hepatitis C Virus Infections
Kenrad E.
Nelson* and
David
L.
Thomas
Departments of Epidemiology and
Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
 |
INTRODUCTION |
Many individuals with hepatitis C
virus (HCV) infection are coinfected with the human immunodeficiency
virus (HIV). Since HCV and HIV are transmitted by parenteral exposure
and both viruses have long clinical latent periods, persons with a
history of illicit injection drug use and receipt of blood or blood
products, such as factor VIII or IX, are commonly infected with both
viruses. It has been estimated that 100,000 to 240,000 of the estimated 900,000 HIV-infected persons in the United States also are infected with HCV, and a similar proportion are coinfected in Europe (T. Benfield, 12th World AIDS Conf., abstr. 22261, 1998). Therefore, it is
important to understand how these two viruses modify one another's
disease course and affect efforts to treat and prevent these common infections.
| |
HCV RNA LEVELS |
For both HIV and HCV, the amount of viral RNA in the
blood (viral load) is believed to represent the steady state of viral replication and clearance. HCV RNA levels tend to be higher in persons
with chronic HCV infection than in adults with HIV infection, and the
HCV half-life is probably shorter than for HIV (18). However, the HCV RNA level does not predict the progression of liver
disease as strongly as the HIV viral load correlates with development
of AIDS (16, 29).
As shown in the study by Mathews-Greer et al. (28), the
HCV viral load is higher in individuals who are coinfected with HIV
than in those without HIV coinfection. This relationship has been
demonstrated both in cross-sectional and in longitudinal studies
(15, 19, 28, 42, 44). In addition, in some but not all
studies there is an inverse relationship between the CD4+
cell count and the HCV RNA level. Persons coinfected with HIV have been
reported to be less likely to clear HCV spontaneously than those
without HIV infection (44). Other factors associated with
an increased HCV RNA level are older age and other forms of immune
suppression (35, 41, 43). Persons who are hepatitis B
surface antigen positive appear to have lower levels of HCV RNA
(40, 42). Despite these factors known to be associated with HCV viral load, most of the variation in HCV viral load between infected individuals remains unexplained (40, 42).
| |
HIV INFECTION AND THE COURSE OF HEPATITIS C |
Several investigators have documented higher rates of
liver-related morbidity and mortality in persons infected with HIV and HCV (1, 3, 4, 8, 14, 25, 26, 35, 37, 40). Eyster et al.
reported that liver failure and liver-related death occurred
exclusively in HCV-infected hemophiliacs who were coinfected with HIV
(11). Likewise, Darby and colleagues reported a fivefold increase in liver-associated mortality in HIV-infected hemophiliacs (who almost certainly had HCV infection) compared to those without HIV
infection (8). Another study reported that HIV coinfection was an independent risk factor for the development of cirrhosis in a
study population of HCV-infected drug users (33). It is not yet clear what the effect of highly active antiretroviral therapy
will be on HCV morbidity and mortality.
Since the incubation period after infection to the development of
cirrhosis, liver failure, or liver cancer usually is many years or
decades, prolonged survival could increase HCV-related morbidity and
mortality. Studies of the immunopathogenesis of liver disease and the
immunologic control of HCV replication in infected individuals are
ongoing. Data published recently suggest that cellular immune
responses, particularly those mediated by CD8+ T
lymphocytes in liver tissue, may be associated with lower levels of HCV
RNA but more active liver disease (30). Nevertheless, the
studies to date suggest that the immunopathology and immunocompromise associated with HIV infection has an adverse effect on the natural history of the progression of HCV infection.
The natural history of HCV and HIV may also be modified among injection
drug users or other high-risk populations by frequent reexposures to
these viruses. The frequency of reinfection with HCV needs further
evaluation. Farci et al. showed that chimpanzees could be reinfected
with the same strain of HCV after they had cleared an initial infection
(17).
| |
HCV INFECTION AND THE COURSE OF HIV |
The data on the impact of HCV infection on HIV progression are
conflicting. Piroth et al. found a more rapid progression of HIV in 119 HCV-coinfected patients compared to controls who were infected only
with HIV (32). Also, that study demonstrated more rapid
CD4+ lymphocyte decline as well as clinical progression of
HIV in HCV-coinfected patients. A study was reported recently of the rate of HIV progression in 207 HCV-HIV-coinfected hemophiliacs who were
monitored prospectively for 7 years after enrollment with annual
measurement of CD4+ lymphocyte cell counts and HCV and HIV viral loads
(9). After controlling for CD4+ counts and
HIV-1 RNA level, every 10-fold increase in baseline HCV RNA was
associated with a relative risk for clinical progression to AIDS of
1.66 (95% confidence interval, 1.03 to 2.30). In another recent study
of members of the large Swiss HIV cohort who started highly active
antiretroviral therapy, those with HCV and HIV coinfection had
more rapid progression to adverse outcomes (21). In
addition, among those whose HIV viral load was reduced below 400 copies/ml, HCV-positive subjects had smaller increases in
CD4+ lymphocyte counts.
In contrast to these reports, other studies have failed to detect a
more rapid progression of HIV in HCV coinfected patients (10, 34,
39, 50). In one study of 416 HIV seroconverters who were
monitored for an average of 3 years, similar rates of progression were
found in the 51.4% who were HCV coinfected compared to those with only
HIV infection (10). Sulkowski et al. found that HCV
infection was not independently associated with progression to AIDS or
death after adjusting for exposure to HAART and CD4+ count
among 1,742 HIV-positive patients (M. S. Sulkowski, D. L. Moore, S. Mehta, S. L. Laughton, and D. L. Thomas, 8th Conf. Retrovir. Opportunistic Infect., abstr. 34, 2001). Aside from the HCV
infection, there are a number of differences between persons with both
HCV and HIV compared to those with HIV infection alone. These factors
may explain differences in the results of published studies. Clearly,
additional studies to evaluate the role of HCV in HIV progression are
needed in order to clarify this interaction.
| |
HIV INFECTION AND TREATMENT OF HEPATITIS C |
Treatment of hepatitis C may be different in an HIV-infected
person for several reasons. Overall rates of sustained clearance of HCV
appear to be reduced in HIV-HCV-coinfected persons, especially those
with advanced HIV infection (38). In addition, it may be
difficult to use ribavirin in persons whose antiretroviral regimen
relies on the activity of either zidovudine or d4T, since phosphorylation to the active compounds may be reduced
(49). Conversely, ribavirin may increase the activity (and
toxicity) of dideoxyinosine, and alpha interferon itself has
antiretroviral activities, reducing the HIV viral load approximately
one-half log.
These considerations notwithstanding, there is an emerging
international experience with treatment of HCV infection in
HIV-HCV-coinfected persons. Soriano and coworkers have made the
important observation that HCV infection can be cured with alpha
interferon therapy in HIV-HCV-coinfected persons (38).
While large studies are under way to assess the safety and efficacy of
interferon (including pegylated interferon) and ribavirin in the
treatment of HCV in the HIV-HCV-coinfected person, there already are a
few reports suggesting their safety and efficacy (24).
| |
HCV INFECTION AND TREATMENT OF HIV |
Chronic HCV infection can affect the response to antiretroviral
therapy. Since the liver is the primary site of HCV replication, the
pharmacokinetics of drugs that are metabolized in the liver may differ
in HCV-HIV-coinfected patients. Although all antiretroviral drugs have
been reported to have hepatotoxicity in some patients, hepatotoxicity
for these and other drugs may be worse in HCV-infected patients
(2, 5, 11, 47). Other investigators have reported enhancement of HCV replication and liver damage in HCV-HIV-coinfected patients treated with antiretroviral combination therapy (23, 27,
36, 39a, 40, 48, 52). Some authors have postulated that the
enhanced liver toxicity in HCV-infected patients receiving antiretroviral therapy could be due to immune restoration
(23). However, other factors clearly are involved since
hepatotoxicity also occurs in persons without apparent CD4+
lymphocyte increases and in those without viral hepatitis.
| |
EFFECT OF HIV ON HCV TRANSMISSION |
HCV is transmitted from an infected mother to her infant after 2 to 5% of deliveries (51). However, HIV-coinfected mothers transmit HCV to their infants more often (22, 45).
The frequency of transmission of HCV by heterosexual or male homosexual
intercourse is controversial (6, 12, 20, 31). Studies of
HCV-infected blood donors have identified multiple sex partners as a
risk factor for HCV prevalence, independent of parenteral exposures
(7). Another study of patients attending a sexually
transmitted disease (STD) clinic found HCV prevalence to be elevated
among clients with an STD who had had unprotected sex with multiple
partners and who denied drug use or other parenteral exposures
(46). The overall evidence to date, however, suggests that
sexual transmission of HCV occurs but that it is substantially less
efficient than the sexual transmission of HBV and HIV. Coinfection with
HIV appears to increase the rate of sexual transmission of HCV. In one
study, 3% of the female partners of HIV-HCV-coinfected male
hemophiliacs were HCV infected, while none of the female partners of
HCV-infected persons without HIV were infected (13).
The reason for the apparent increased sexual transmission from
HIV-HCV-coinfected persons is unknown. Although HCV RNA has been
identified in genital secretions (i.e., vaginal washes and semen),
there appears to be quantitatively less than in blood. HCV RNA levels
are higher in HIV-infected persons, but it is probably too simplistic
to presume that greater circulating levels themselves explain the
enhanced transmission. The relationship between HCV RNA level and
sexual transmission has not been evaluated, as it has with HIV
infection. However, despite the fact that HCV RNA levels in the plasma
often exceed those seen in persons with HIV or HBV infection, sexual or
other nonparenteral transmission is uncommon. Little is known at
present about how HCV crosses mucosal barriers when and if it does.
In summary, there are many interactions between HCV and HIV. It is
important that research efforts be increased in order to better
understand HIV-HCV coinfection and the optimal means of treating the
large number of coinfected persons.
| |
FOOTNOTES |
*
Corresponding author. Mailing address: Department of
Epidemiology, School of Hygiene and Public Health, Johns Hopkins
University, 615 N. Wolfe St., Baltimore, MD 21205. Phone: (410)
955-1296. Fax: (410) 955-1836. E-mail: kenelson{at}jhsph.edu.
The views expressed in this Commentary do not necessarily
reflect the views of the journal or of ASM.
| |
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Clinical and Diagnostic Laboratory Immunology, September 2001, p. 867-870, Vol. 8, No. 5
1071-412X/01/$04.00+0 DOI: 10.1128/CDLI.8.5.867-870.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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Introduction
References
