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Applied and Environmental Microbiology, September 2005, p. 5630-5632, Vol. 71, No. 9
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.9.5630-5632.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SHORT REPORT

Secretion of Recombinant Pediocin PA-1 by Bifidobacterium longum, Using the Signal Sequence for Bifidobacterial {alpha}-Amylase

Gi-Seong Moon,1 Yu-Ryang Pyun,2 Myeong Soo Park,3 Geun Eog Ji,3,4 and Wang June Kim1*

Food Safety Research Division, Korea Food Research Institute, Seongnam, Gyeonggi 463-746, Korea,1 Department of Biotechnology, Yonsei University, Seoul 120-749, Korea,2 Research Center, BIFIDO Co., Ltd., Seoul 151-818, Korea,3 Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea4

Received 7 November 2004/ Accepted 14 April 2005

A recombinant DNA, encoding the chimeric protein of the signal sequence for bifidobacterial {alpha}-amylase mature pediocin PA-1, was introduced into Bifidobacterium longum MG1. Biologically active pediocin PA-1 was successfully secreted from the strain and showed bactericidal activity against Listeria monocytogenes and the same molecular mass as native pediocin PA-1.

* Corresponding author. Mailing address: Food Safety Research Division, Korea Food Research Institute, San 46-1, Baekhyun-Dong, Bundang-Gu, Seongnam, Gyeonggi 463-746, Korea. Phone: 82-31-780-9110. Fax: 82-31-709-9876. E-mail: wjkim{at}kfri.re.kr.

Applied and Environmental Microbiology, September 2005, p. 5630-5632, Vol. 71, No. 9
0099-2240/05/$08.00+0     doi:10.1128/AEM.71.9.5630-5632.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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Copyright © 2005 by the American Society for Microbiology. All rights reserved.