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Antimicrobial Agents and Chemotherapy, June 2005, p. 2571-2572, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2571-2572.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Posttreatment Changes in Escherichia coli Antimicrobial Susceptibility Rates among Diarrheic Patients Treated with Ciprofloxacin

Shannon D. Putnam,1* John W. Sanders,2 David R. Tribble,3 David R. Rockabrand,1 Mark S. Riddle,1 Patrick J. Rozmajzl,1 and Robert W. Frenck1

Naval Medical Research Unit 2, Jakarta, Indonesia,1 Naval Medical Research Unit 3, Cairo, Egypt,2 Naval Medical Research Center, Silver Spring, Maryland3

Received 23 November 2004/ Returned for modification 8 January 2005/ Accepted 21 February 2005

Changes in antimicrobial resistance of Escherichia coli among deployed U.S. military personnel being treated for diarrhea were evaluated. Stool samples were collected pretreatment and on days 7, 14, and 28 posttreatment. Resistance to ciprofloxacin was noted in 13.3% of baseline specimens, and rates of resistance against multiple antibiotics increased dramatically from baseline to day 7 and then tapered off to return to pretreatment levels by day 28, except for ciprofloxacin, suggesting that population accumulative usage of fluoroquinolones may result in an incremental increase in resistance rates.

* Corresponding author. Mailing address: U.S. Embassy Jakarta, NAMRU2 Box 8132, FPO AP 96520. Phone: 62 21 421 4457, ext. 1126. Fax: 62 21 420 7854. E-mail: Putnam{at}namru2.org.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2571-2572, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2571-2572.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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