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Antimicrobial Agents and Chemotherapy, March 2005, p. 1201-1202, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1201-1202.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Activity of Cathelicidin Peptides against Chlamydia spp.

Sezione di Microbiologia, DMCSS, Policlinico S. Orsola, University of Bologna, Bologna,¹ Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Trieste, Italy²

Received 15 July 2004/ Returned for modification 29 August 2004/ Accepted 31 October 2004

The in vitro activity of six cathelicidin peptides against 25 strains of Chlamydia was investigated. SMAP-29 proved to be the most active peptide, reducing the inclusion numbers of all 10 strains of Chlamydia trachomatis tested by 50% at 10 µg/ml. This peptide was also active against C. pneumoniae and C. felis.

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