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Antimicrobial Agents and Chemotherapy, February 2005, p. 801-803, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.801-803.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cloning of a Novel Gene for Quinolone Resistance from a Transferable Plasmid in Shigella flexneri 2b

Department of Microbiology, Aichi Prefectural Institute of Public Health,¹ Clinical Research Center, Nagoya Medical Center, Nagoya, Aichi, Japan²

Received 30 August 2004/ Returned for modification 26 September 2004/ Accepted 13 October 2004

A novel gene for quinolone resistance was cloned from a transferable plasmid carried by a clinical isolate of Shigella flexneri 2b that was resistant to fluoroquinolones. The plasmid conferred low-level resistance to quinolones on Escherichia coli HB101. The protein encoded by the gene showed 59% amino acid identity with Qnr.

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