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Antimicrobial Agents and Chemotherapy, November 2001, p. 3195-3197, Vol. 45, No. 11
Biological Research
Laboratories1 and Laboratory Animal
Science and Toxicology Research
Laboratories,2 Sankyo Co., Ltd.,
Shinagawa-ku, Tokyo 140-8710, Japan, and Harbor-UCLA
Research and Education Institute, Torrance, California
905023
Received 9 February 2001/Returned for modification 6 June
2001/Accepted 3 August 2001
We established a straightforward murine model of oropharyngeal
candidiasis. Mice were immunosuppressed with cortisone acetate, anesthetized, and then inoculated by placing cotton wool balls saturated with Candida albicans sublingually for 2 h. A prolonged, reproducible infection was induced. This model may be
useful for antifungal screening or pathogenesis studies.
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.11.3195-3197.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
New Model of Oropharyngeal Candidiasis in
Mice
*
Corresponding author. Mailing address: Biological Research
Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo, 140-8710, Japan. Phone: 81-3-3492-3131. Fax: 81-3-5436-8565. E-mail: ykamai{at}shina.sankyo.co.jp.
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