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Antimicrobial Agents and Chemotherapy, December 2007, p. 4505-4507, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00771-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate{triangledown}

Kerry C. Carson,1* Jessica G. Bartlett,1 Trina-Jean Tan,1 and Thomas V. Riley1,2

Microbiology and Infectious Disease, PathWest Laboratory Medicine WA,1 Microbiology and Immunology, The University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia2

Received 15 June 2007/ Returned for modification 12 July 2007/ Accepted 21 September 2007

The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (≥1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10–9, and serial passage could not extend growth beyond 1.6x MIC.

* Corresponding author. Mailing address: Division of Microbiology & Infectious Diseases, PathWest Laboratory Medicine WA, Locked Bag 2009, Nedlands, Western Australia 6909, Australia. Phone: 61 8 9346 4092. Fax: 61 8 9382 8046. E-mail: k-carson{at}cyllene.uwa.edu.au

{triangledown} Published ahead of print on 1 October 2007.

Antimicrobial Agents and Chemotherapy, December 2007, p. 4505-4507, Vol. 51, No. 12
0066-4804/07/$08.00+0     doi:10.1128/AAC.00771-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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