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Sci. STKE, 16 May 2006
Vol. 2006, Issue 335, p. re4
[DOI: 10.1126/stke.3352006re4]

REVIEWS

Notch and Wnt Signaling: Mimicry and Manipulation by Gamma Herpesviruses

S. Diane Hayward1*, Jianyong Liu1, and Masahiro Fujimuro2

1Viral Oncology Program, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA.
2Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Abstract: A small number of fundamental cell signaling pathways are key to the regulation of proliferation and differentiation responses during normal development. Two of these pathways, the Notch and Wnt pathways, have proven to be attractive targets for virus interaction and manipulation. In general, viral gene expression and replication are intimately linked to the differentiation state of the infected cell and, in the case of the gamma herpesviruses, establishment of a lifelong persistent infection in the host is also dependent on the proliferative expansion of an infected B cell population. This review examines the ways in which the gamma herpesviruses Epstein-Barr virus (EBV) and Kaposi’s sarcoma–associated herpesvirus (KSHV) have exploited the Notch and Wnt pathways to advance their own life cycles. The virus-pathway interactions are compared with the mechanisms and outcome of cellular Notch and Wnt signaling.

*Corresponding author. Telephone, (410) 614-0592; fax, (410) 502-6802; e-mail, dhayward{at}jhmi.edu

Citation: S. D. Hayward, J. Liu, M. Fujimuro, Notch and Wnt Signaling: Mimicry and Manipulation by Gamma Herpesviruses. Sci. STKE 2006, re4 (2006).

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