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Science 2 July 1976:
Vol. 193. no. 4247, pp. 70 - 72
DOI: 10.1126/science.935859
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Articles

Science, Vol 193, Issue 4247, 70-72
Copyright © 1976 by American Association for the Advancement of Science

articles

Isolations of a cartilage factor that inhibits tumor neovascularization

R Langer, H Brem, K Falterman, M Klein, and J Folkman

A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)