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Science 21 October 1977:
Vol. 198. no. 4314, pp. 313 - 314
DOI: 10.1126/science.910131
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Articles

Science, Vol 198, Issue 4314, 313-314
Copyright © 1977 by American Association for the Advancement of Science

articles

Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers

RJ Rodriguez, RR White, RM Senior, and EA Levine

Alveolar macrophages from smokers, in contrast to those of non-smokers, release elastase into serum-free culture medium. Since enzymes that digest elastin produce pulmonary emphysema in experimental animals, release of elastase by alveolar macrophages from smokers suggests that these cells are important in the pathogenesis of emphysema of smokers.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)