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Science 20 August 1976:
Vol. 193. no. 4254, pp. 673 - 675
DOI: 10.1126/science.781840
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Articles

Science, Vol 193, Issue 4254, 673-675
Copyright © 1976 by American Association for the Advancement of Science

articles

Human malaria parasites in continuous culture

W Trager and JB Jensen

Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen (1 or 5 percent). The original parasite material, derived from an infected Aotus trivirgatus monkey, was diluted more than 100 million times by the addition of human erythrocytes at 3- or 4-day intervals. The parasites continued to reproduce in their normal asexual cycle of approximately 48 hours but were no longer highly synchronous. The have remained infective to Aotus.


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A Conserved Region in the EBL Proteins Is Implicated in Microneme Targeting of the Malaria Parasite Plasmodium falciparum.
M. Treeck, N. S. Struck, S. Haase, C. Langer, S. Herrmann, J. Healer, A. F. Cowman, and T. W. Gilberger (2006)
J. Biol. Chem. 281, 31995-32003
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Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo.
C. Casals-Pascual, O. Kai, J. O. P. Cheung, S. Williams, B. Lowe, M. Nyanoti, T. N. Williams, K. Maitland, M. Molyneux, C. R. J. C. Newton, et al. (2006)
Blood 108, 2569-2577
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Potent Antihematozoan Activity of Novel Bisthiazolium Drug T16: Evidence for Inhibition of Phosphatidylcholine Metabolism in Erythrocytes Infected with Babesia and Plasmodium spp..
E. Richier, G. A. Biagini, S. Wein, F. Boudou, P. G. Bray, S. A. Ward, E. Precigout, M. Calas, J.-F. Dubremetz, and H. J. Vial (2006)
Antimicrob. Agents Chemother. 50, 3381-3388
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Immunogenicity of Duffy Binding-Like Domains That Bind Chondroitin Sulfate A and Protection against Pregnancy-Associated Malaria..
N. Bir, S. S. Yazdani, M. Avril, C. Layez, J. Gysin, and C. E. Chitnis (2006)
Infect. Immun. 74, 5955-5963
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PfPKB, a Protein Kinase B-like Enzyme from Plasmodium falciparum: II. IDENTIFICATION OF CALCIUM/CALMODULIN AS ITS UPSTREAM ACTIVATOR AND DISSECTION OF A NOVEL SIGNALING PATHWAY.
A. Vaid and P. Sharma (2006)
J. Biol. Chem. 281, 27126-27133
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pfmdr2 Confers Heavy Metal Resistance to Plasmodium falciparum.
E. Rosenberg, I. Litus, N. Schwarzfuchs, R. Sinay, P. Schlesinger, J. Golenser, S. Baumeister, K. Lingelbach, and Y. Pollack (2006)
J. Biol. Chem. 281, 27039-27045
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Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum..
K. M. Massimine, M. T. McIntosh, L. T. Doan, C. E. Atreya, S. Gromer, W. Sirawaraporn, D. A. Elliott, K. A. Joiner, R. H. Schirmer, and K. S. Anderson (2006)
Antimicrob. Agents Chemother. 50, 3132-3141
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In Vitro Interactions between Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs..
T. M. E. Davis, J. Hamzah, K. F. Ilett, H. A. Karunajeewa, J. C. Reeder, K. T. Batty, S. Hackett, and P. H. R. Barrett (2006)
Antimicrob. Agents Chemother. 50, 2883-2885
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Effect of Sequence Variation in Plasmodium falciparum Histidine- Rich Protein 2 on Binding of Specific Monoclonal Antibodies: Implications for Rapid Diagnostic Tests for Malaria..
N. Lee, J. Baker, K. T. Andrews, M. L. Gatton, D. Bell, Q. Cheng, and J. McCarthy (2006)
J. Clin. Microbiol. 44, 2773-2778
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Programmed Transcription of the var Gene Family, but Not of stevor, in Plasmodium falciparum Gametocytes..
S. Sharp, T. Lavstsen, Q. L. Fivelman, M. Saeed, L. McRobert, T. J. Templeton, A. T. R. Jensen, D. A. Baker, T. G. Theander, and C. J. Sutherland (2006)
Eukaryot. Cell 5, 1206-1214
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A Cluster of Ring Stage-specific Genes Linked to a Locus Implicated in Cytoadherence in Plasmodium falciparum Codes for PEXEL-negative and PEXEL-positive Proteins Exported into the Host Cell.
T. Spielmann, P. L. Hawthorne, M. W.A. Dixon, M. Hannemann, K. Klotz, D. J. Kemp, N. Klonis, L. Tilley, K. R. Trenholme, and D. L. Gardiner (2006)
Mol. Biol. Cell 17, 3613-3624
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Localization of the Phosphoethanolamine Methyltransferase of the Human Malaria Parasite Plasmodium falciparum to the Golgi Apparatus.
W. H. Witola, G. Pessi, K. El Bissati, J. M. Reynolds, and C. B. Mamoun (2006)
J. Biol. Chem. 281, 21305-21311
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A Set of Glycosylphosphatidyl Inositol-Anchored Membrane Proteins of Plasmodium falciparum Is Refractory to Genetic Deletion.
P. R. Sanders, L. M. Kats, D. R. Drew, R. A. O'Donnell, M. O'Neill, A. G. Maier, R. L. Coppel, and B. S. Crabb (2006)
Infect. Immun. 74, 4330-4338
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