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Science 10 March 1995:
Vol. 267. no. 5203, pp. 1449 - 1456
DOI: 10.1126/science.7533326
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Articles

Science, Vol 267, Issue 5203, 1449-1456
Copyright © 1995 by American Association for the Advancement of Science

articles

The Fas death factor

S Nagata and P Golstein

Osaka Bioscience Institute, Japan.

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)