Gerald M. Rubin,
1
Mark D. Yandell,
3
Jennifer R. Wortman,
3
George L. Gabor Miklos,
4
Catherine R. Nelson,
2
Iswar K. Hariharan,
5
Mark E. Fortini,
6
Peter W. Li,
3
Rolf Apweiler,
7
Wolfgang Fleischmann,
7
J. Michael Cherry,
8
Steven Henikoff,
9
Marian P. Skupski,
3
Sima Misra,
2
Michael Ashburner,
7
Ewan Birney,
7
Mark S. Boguski,
10
Thomas Brody,
11
Peter Brokstein,
2
Susan E. Celniker,
12
Stephen A. Chervitz,
13
David Coates,
14
Anibal Cravchik,
3
Andrei Gabrielian,
3
Richard F. Galle,
12
William M. Gelbart,
15
Reed A. George,
12
Lawrence S. B. Goldstein,
16
Fangcheng Gong,
3
Ping Guan,
3
Nomi L. Harris,
12
Bruce A. Hay,
17
Roger A. Hoskins,
12
Jiayin Li,
3
Zhenya Li,
3
Richard O. Hynes,
18
S. J. M. Jones,
19
Peter M. Kuehl,
20
Bruno Lemaitre,
21
J. Troy Littleton,
22
Deborah K. Morrison,
23
Chris Mungall,
12
Patrick H. O'Farrell,
24
Oxana K. Pickeral,
10
Chris Shue,
3
Leslie B. Vosshall,
25
Jiong Zhang,
10
Qi Zhao,
3
Xiangqun H. Zheng,
3
Fei Zhong,
3
Wenyan Zhong,
3
Richard Gibbs,
26
J. Craig Venter,
3
Mark D. Adams,
3
Suzanna Lewis
2
A comparative analysis of the genomes of
Drosophila melanogaster, Caenorhabditis elegans,
and Saccharomyces cerevisiae--and the proteins they are
predicted to encode--was undertaken in the context of cellular,
developmental, and evolutionary processes. The nonredundant protein
sets of flies and worms are similar in size and are only twice that of
yeast, but different gene families are expanded in each genome, and the
multidomain proteins and signaling pathways of the fly and worm are far
more complex than those of yeast. The fly has orthologs to 177 of the
289 human disease genes examined and provides the foundation for rapid
analysis of some of the basic processes involved in human disease.
1 Howard Hughes Medical Institute,
2 Department of Molecular and Cell Biology, Berkeley
Drosophila Genome Project, University of California,
Berkeley, CA 94720, USA.
3 Celera Genomics,
Rockville, MD, 20850 USA.
4 GenetixXpress, 78 Pacific Road, Palm Beach, Sydney, Australia 2108.
5 Massachusetts General Hospital Cancer Center,
Building 149, 13th Street, Charlestown, MA 02129 USA.
6 Department of Genetics, University of Pennsylvania
School of Medicine, Philadelphia, PA 19104, USA.
7 EMBL-EBI, Wellcome Trust Genome Campus, Hinxton,
Cambridge CB10 1SD, UK.
8 Department of Genetics,
Stanford University, Palo Alto, CA 94305, USA.
9 Howard Hughes Medical Institute, Fred Hutchinson
Cancer Research Center, Seattle, WA 98109, USA.
10 National Center for Biotechnology Information,
National Library of Medicine, National Institutes of Health, Bethesda,
MD 20894, USA.
11 Neurogenetics Unit, Laboratory of
Neurochemistry, National Institute of Neurological Disorders and
Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
12 Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
13 Neomorphic, 2612 Eighth Street, Berkeley, CA
94710, USA.
14 School of Biology, University of
Leeds, Leeds LS2 9JT, UK.
15 Department of
Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue,
Cambridge, MA 02138, USA.
16 Departments of
Cellular and Molecular Medicine and Pharmacology, Howard Hughes Medical
Institute, University of California-San Diego, La Jolla, CA 92093, USA.
17 Division of Biology, California Institute
of Technology, Pasadena, CA 91125, USA.
18 Howard
Hughes Medical Institute, Massachusetts Institute of Technology
(MIT), Cambridge, MA 02139, USA.
19 Genome
Sequence Centre, BC Cancer Research Centre, 600 West 10th Avenue,
Vancouver, BC, V52 4E6, Canada.
20 Molecular and
Cell Biology Program, University of Maryland at Baltimore, Baltimore,
MD 21201, USA.
21 Centre de Génétique
Moléculaire, CNRS, 91198 Gif-sur-Yvette, France.
22 Center for Learning and Memory, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
23 Regulation of Cell Growth Laboratory, Division
of Basic Sciences, National Cancer Institute-Frederick Cancer Research
and Development Center, National Institutes of Health, Frederick, MD
21702, USA.
24 Department of Biochemistry and
Biophysics, University of California, San Francisco, CA 94143, USA.
25 Center for Neurobiology and Behavior, Columbia
University, New York, NY 10032, USA.
26 Baylor
College of Medicine Human Genome Sequencing Center, Department of
Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
77030, USA.
