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Science 13 August 1999:
Vol. 285. no. 5430, pp. 1028 - 1033
DOI: 10.1126/science.285.5430.1028
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Review

Integrin Signaling

Filippo G. Giancotti, 1 Erkki Ruoslahti 2

Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate.

1 Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. E-mail: f-giancotti{at}ski.mskcc.org
2 Cancer Research Center, The Burnham Institute, La Jolla, CA 92027, USA. E-mail: ruoslahti{at}burnham.inst.org

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2,3,7,8-Tetrachlorodibenzo-p-dioxin and Epidermal Growth Factor Cooperatively Suppress Peroxisome Proliferator-Activated Receptor-{gamma}1 Stimulation and Restore Focal Adhesion Complexes during Adipogenesis: Selective Contributions of Src, Rho, and Erk Distinguish These Overlapping Processes in C3H10T1/2 Cells.
X. Liu and C. Jefcoate (2006)
Mol. Pharmacol. 70, 1902-1915
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Protease Activity, Secretion, Cell Entry, Cytotoxicity, and Cellular Targets of Secreted Autotransporter Toxin of Uropathogenic Escherichia coli.
N. M. Maroncle, K. E. Sivick, R. Brady, F.-E. Stokes, and H. L. T. Mobley (2006)
Infect. Immun. 74, 6124-6134
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HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation.
H. Xu, L. Zeng, H. Peng, S. Chen, J. Jones, T.-L. Chew, M. M. Sadeghi, Y. S. Kanwar, and F. R. Danesh (2006)
Am J Physiol Renal Physiol 291, F995-F1004
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Stable Knockdown of Polycystin-1 Confers Integrin-{alpha}2beta1-Mediated Anoikis Resistance.
L. Battini, E. Fedorova, S. Macip, X. Li, P. D. Wilson, and G. L. Gusella (2006)
J. Am. Soc. Nephrol. 17, 3049-3058
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beta4 Integrin and Epidermal Growth Factor Coordinately Regulate Electric Field-mediated Directional Migration via Rac1.
C. E. Pullar, B. S. Baier, Y. Kariya, A. J. Russell, B. A.J. Horst, M. P. Marinkovich, and R. R. Isseroff (2006)
Mol. Biol. Cell