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Science 19 February 1999:
Vol. 283. no. 5405, pp. 1183 - 1186
DOI: 10.1126/science.283.5405.1183
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Reports

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

Marie-Clotilde Rissoan, 1* Vassili Soumelis, 1* Norimitsu Kadowaki, 2* Geraldine Grouard, 1 Francine Briere, 1 René de Waal Malefyt, 2 Yong-Jun Liu 12dagger

It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+CD3-CD11c- plasmacytoid cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-gamma . Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.

1 Schering-Plough, Laboratory for Immunological Research, 27 chemin des Peupliers, Boite Postale 11, 69571, Dardilly, France.
2 DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304-1104, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: yliu{at}dnax.org

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Science. ISSN 0036-8075 (print), 1095-9203 (online)