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Science 30 October 1998:
Vol. 282. no. 5390, pp. 943 - 946
DOI: 10.1126/science.282.5390.943
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Reports

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

Yi-Jyun Lin, Laurent Seroude, Seymour Benzer *

Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah (mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
*   To whom correspondence should be addressed. E-mail: benzer{at}caltech.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)