Suppression of TNF-
-Induced Apoptosis by NF-
B
Daniel J. Van Antwerp,
Seamus J. Martin,
*
Tal Kafri,
Douglas R. Green,
Inder M. Verma
Tumor necrosis factor 
(TNF-) signaling gives rise to
a number of events, including activation of transcription factor
NF-
B and programmed cell death (apoptosis). Previous studies of
TNF- signaling have suggested that these two events occur
independently. The sensitivity and kinetics of TNF--induced
apoptosis are shown to be enhanced in a number of cell types expressing
a dominant-negative IB (IBM). These findings suggest that a
negative feedback mechanism results from TNF- signaling in which
NF-B activation suppresses the signals for cell death.
D. J. Van Antwerp, Laboratory of Genetics, Salk Institute, La
Jolla, CA 92037, and Department of Chemistry and Biochemistry,
University of California, San Diego, CA 92093, USA.
S. J. Martin and D. R. Green, La Jolla Institute for Allergy and
Immunology, San Diego, CA 92121, USA.
T. Kafri and I. M. Verma, Laboratory of Genetics, Salk Institute, La
Jolla, CA 92037, USA.
*
Present address: Molecular Cell Biology Laboratory, Department of
Biology, Maynooth College, Maynooth, County Kildare, Ireland.
To whom correspondence should be addressed.
