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Science 8 April 1988:
Vol. 240. no. 4849, pp. 177 - 184
DOI: 10.1126/science.2451290
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Articles

Science, Vol 240, Issue 4849, 177-184
Copyright © 1988 by American Association for the Advancement of Science

articles

Cell and environment interactions in tumor microregions: the multicell spheroid model

RM Sutherland

Cancer Center for Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, NY 14642.

Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)