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Science 19 January 1990:
Vol. 247. no. 4940, pp. 322 - 324
DOI: 10.1126/science.2296722
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Articles

Science, Vol 247, Issue 4940, 322-324
Copyright © 1990 by American Association for the Advancement of Science

articles

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

AR Moser, HC Pitot, and WF Dove

McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706.

In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)