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Science 30 October 1992:
Vol. 258. no. 5083, pp. 766 - 770
DOI: 10.1126/science.1439783
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Articles

Science, Vol 258, Issue 5083, 766-770
Copyright © 1992 by American Association for the Advancement of Science

articles

What if Minkowski had been ageusic? An alternative angle on diabetes

JD McGarry

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.

Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)