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Science 22 November 1963:
Vol. 142. no. 3595, pp. 1069 - 1070
DOI: 10.1126/science.142.3595.1069
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Articles

Hydroxyurea: Mechanism of Action

William N. Fishbein 1 and Paul P. Carbone 1

1 Medicine Branch, National Cancer Institute, Bethesda, Maryland

Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-coenzyme A.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)