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Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"
Gad Getz,1*Holger Höfling,2*Jill P. Mesirov,1Todd R. Golub,1,3,4,5,6Matthew Meyerson,1,3Robert Tibshirani,2,7Eric S. Lander1,6,8
Sjöblom et al. (Research Article, 13 October 2006, p. 268)reported nearly 200 novel cancer genes said to have a 90% probabilityof being involved in colon or breast cancer. However, theiranalysis raises two statistical concerns. When these concernsare addressed, few genes with significantly elevated mutationrates remain. Although the biological methodology in Sjöblomet al. is sound, more samples are needed to achieve sufficientpower.
1 Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA. 2 Department of Statistics, Stanford University, Stanford, CA 94305, USA. 3 Dana-Farber Cancer Institute, Boston, MA 02115, USA. 4 Department of Medicine, Children's Hospital Boston, Boston, MA 02115, USA. 5 Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. 6 Harvard Medical School, Boston, MA 02115, USA. 7 Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA. 8 Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: gadgetz{at}broad.mit.edu
Giovanni Parmigiani, Jimmy Lin, Simina M. Boca, Tobias Sjöblom, Siân Jones, Laura D. Wood, D. Williams Parsons, Thomas Barber, Phillip Buckhaults, Sanford D. Markowitz, Ben Ho Park, Kurtis E. Bachman, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W. Kinzler, and Victor E. Velculescu (14 September 2007) Science317 (5844), 1500d.
[DOI: 10.1126/science.1138773] |Abstract »|Full Text »|PDF »|Supporting Online Material »
RESEARCH ARTICLES
Tobias Sjöblom, Siân Jones, Laura D. Wood, D. Williams Parsons, Jimmy Lin, Thomas D. Barber, Diana Mandelker, Rebecca J. Leary, Janine Ptak, Natalie Silliman, Steve Szabo, Phillip Buckhaults, Christopher Farrell, Paul Meeh, Sanford D. Markowitz, Joseph Willis, Dawn Dawson, James K. V. Willson, Adi F. Gazdar, James Hartigan, Leo Wu, Changsheng Liu, Giovanni Parmigiani, Ben Ho Park, Kurtis E. Bachman, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W. Kinzler, and Victor E. Velculescu (13 October 2006) Science314 (5797), 268.
[DOI: 10.1126/science.1133427] |Abstract »|Full Text »|PDF »|Supporting Online Material »
To whom correspondence should be addressed. E-mail: 
