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Contrary to the findings of Herbert et al. (Reports, 14 April2006, p. 279), homozygous carriers of the C allele of the rs7566605variant near the INSIG2 gene did not exhibit a significantlyincreased risk for obesity in a large population-based cross-sectionalGerman study. A subgroup analysis, however, revealed that thisallele significantly increased the risk for obesity in alreadyoverweight individuals.
1 Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Germany. 2 Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University of Greifswald, Germany.
* To whom correspondence should be addressed. E-mail: dieter.rosskopf{at}uni-greifswald.de
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