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Research ArticlesThe Neurospora Checkpoint Kinase 2: A Regulatory Link Between the Circadian and Cell CyclesThe clock gene period-4 (prd-4) in Neurospora was identified by a single allele displaying shortened circadian period and altered temperature compensation. Positional cloning followed by functional tests show that PRD-4 is an ortholog of mammalian checkpoint kinase 2 (Chk2). Expression of prd-4 is regulated by the circadian clock and, reciprocally, PRD-4 physically interacts with the clock component FRQ, promoting its phosphorylation. DNA-damaging agents can reset the clock in a manner that depends on time of day, and this resetting is dependent on PRD-4. Thus, prd-4, the Neurospora Chk2, identifies a molecular link that feeds back conditionally from circadian output to input and the cell cycle.
1 Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. * To whom correspondence should be addressed. E-mail: jay.c.dunlap{at}dartmouth.edu (J.C.D.); jennifer.loros{at}dartmouth.edu (J.J.L.)
The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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