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Originally published in Science Express on 26 January 2006
Science 17 March 2006:
Vol. 311. no. 5767, pp. 1576 - 1580
DOI: 10.1126/science.1121586
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Research Articles

Large-Scale Sequence Analysis of Avian Influenza Isolates

John C. Obenauer,1 Jackie Denson,1 Perdeep K. Mehta,1 Xiaoping Su,1 Suraj Mukatira,1 David B. Finkelstein,1 Xiequn Xu,1 Jinhua Wang,1 Jing Ma,1 Yiping Fan,1 Karen M. Rakestraw,1 Robert G. Webster,2,4 Erich Hoffmann,2 Scott Krauss,2 Jie Zheng,3 Ziwei Zhang,3 Clayton W. Naeve1,4*

The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.

1 Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
2 Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
3 Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
4 Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

* To whom correspondence should be addressed. E-mail: clayton.naeve{at}stjude.org

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Science. ISSN 0036-8075 (print), 1095-9203 (online)