New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain

doi:10.1126/science.1119133

Account Information

Guest Alerts | Access Rights | My Account | Sign In

Site Navigation

Article Views

VERSION HISTORY

311/5761/629 (most recent)
1119133v1

Article Tools

My Science

More Information

Related Jobs from ScienceCareers

Neuroscience

Originally published in Science Express on 12 January 2006
Science 3 February 2006:
Vol. 311. no. 5761, pp. 629 - 632
DOI: 10.1126/science.1119133

Prev | Table of Contents | Next

Research Articles

New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain

Kazunobu Sawamoto,¹^,4^,5^* Hynek Wichterle,³ Oscar Gonzalez-Perez,¹ Jeremy A. Cholfin,¹^,2 Masayuki Yamada,⁶ Nathalie Spassky,¹ Noel S. Murcia,⁷ Jose Manuel Garcia-Verdugo,⁸ Oscar Marin,⁹ John L. R. Rubenstein,² Marc Tessier-Lavigne,¹⁰ Hideyuki Okano,⁵ Arturo Alvarez-Buylla¹^*

In the adult brain, neuroblasts born in the subventricular zonemigrate from the walls of the lateral ventricles to the olfactorybulb. How do these cells orient over such a long distance andthrough complex territories? Here we show that neuroblast migrationparallels cerebrospinal fluid (CSF) flow. Beating of ependymalcilia is required for normal CSF flow, concentration gradientformation of CSF guidance molecules, and directional migrationof neuroblasts. Results suggest that polarized epithelial cellscontribute important vectorial information for guidance of young,migrating neurons.

¹ Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA.
² Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, CA 94143, USA.
³ Department of Pathology, Columbia University, New York, NY 10032, USA.
⁴ Bridgestone Laboratory of Developmental and Regenerative Neurobiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
⁵ Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
⁶ Central Institute for Experimental Animals, Kawasaki, Kanagawa 216-0001, Japan.
⁷ Rainbow Center for Childhood Polycystic Kidney Disease, Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106–6003, USA.
⁸ University of Valencia, Burjassot-46100, Spain.
⁹ Instituto de Neurosciencias de Alicante of the Consejo Superior de Investigaciones Científicas (CSIC) and University Miguel Hernández, 03550 Sant Joan d'Alacant, Alicante, Spain.
¹⁰ Genentech, Inc., South San Francisco, CA 94080–4990, USA.

^* To whom correspondence should be addressed. E-mail: sawamoto{at}sc.itc.keio.ac.jp (K.S.); abuylla{at}stemcell.ucsf.edu (A.A.B.)

Read the Full Text

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
NEUROBIOLOGY
Neurons Navigate Downstream: (7 February 2006)
Sci. STKE 2006 (321), tw54. [DOI: 10.1126/stke.3212006tw54]
| Abstract »