Comment on "Evidence for Positive Epistasis in HIV-1"

doi:10.1126/science.1109904

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Comment on "Evidence for Positive Epistasis in HIV-1"

Kai Wang, John E. Mittler, Ram Samudrala^*

Bonhoeffer et al. (Reports, 26 November 2004, p. 1547) presentedevidence for positive epistasis in a clinical data set of HIV-1mutants and corresponding fitness values. We demonstrate thatbiases in the original and simulated data sets may lead to erroneousevidence for epistasis. More rigorous statistical tests mustbe used to account for such biases before one can infer epistasis.

Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

^* To whom correspondence should be addressed. E-mail: ram{at}compbio.washington.edu

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TECHNICAL COMMENTS Response to Comment on "Evidence for Positive Epistasis in HIV-1": Sebastian Bonhoeffer, Colombe Chappey, Neil T. Parkin, Jeannette M. Whitcomb, and Christos J. Petropoulos (12 May 2006)
Science 312 (5775), 848c. [DOI: 10.1126/science.1110994]
| Abstract » | Full Text » | PDF »

REPORTS Evidence for Positive Epistasis in HIV-1: Sebastian Bonhoeffer, Colombe Chappey, Neil T. Parkin, Jeanette M. Whitcomb, and Christos J. Petropoulos (26 November 2004)
Science 306 (5701), 1547. [DOI: 10.1126/science.1101786]
| Abstract » | Full Text » | PDF » | Supporting Online Material »