Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

doi:10.1126/science.1104935

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Neuroscience

Science 24 December 2004:
Vol. 306. no. 5705, pp. 2255 - 2257
DOI: 10.1126/science.1104935

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Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

Paul A. Gray,¹^,3^* Hui Fu,²^,3^* Ping Luo,¹^,3^* Qing Zhao,⁴ Jing Yu,⁵ Annette Ferrari,³ Toyoaki Tenzen,⁵ Dong-in Yuk,⁴ Eric F. Tsung,⁶ Zhaohui Cai,⁶ John A. Alberta,³ Le-ping Cheng,¹^,3 Yang Liu,¹^,3 Jan M. Stenman,⁵ M. Todd Valerius,⁵ Nathan Billings,⁴ Haesun A. Kim,²^,3 Michael E. Greenberg,¹^,8 Andrew P. McMahon,⁵ David H. Rowitch,⁴^,7 Charles D. Stiles,²^,3^|| Qiufu Ma¹^,3^||

In the developing brain, transcription factors (TFs) directthe formation of a diverse array of neurons and glia. We identifed1445 putative TFs in the mouse genome. We used in situ hybridizationto map the expression of over 1000 of these TFs and TF-coregulatorgenes in the brains of developing mice. We found that 349 ofthese genes showed restricted expression patterns that wereadequate to describe the anatomical organization of the brain.We provide a comprehensive inventory of murine TFs and theirexpression patterns in a searchable brain atlas database.

¹ Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
³ Department of Cancer Biology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA.
⁴ Department of Pediatric Oncology, Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA.
⁵ Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
⁶ Informatics Program, Children's Hospital, Boston, MA 02115, USA.
⁷ Division of Newborn Medicine, Children's Hospital, Boston, MA 02115, USA.
⁸ Division of Neuroscience, Children's Hospital, Boston, MA 02115, USA.

^* These authors contributed equally to this work.

Present address: Molecular Neurobiology Laboratory, The SalkInstitute, 10010 North Torrey Pines Road, La Jolla, CA 92037,USA.

Present address: Department of Biology, Boston College, 140Commonwealth Avenue, Chestnut Hill, MA 02467, USA.

Present address: Department of Biological Sciences, RutgersUniversity, 101 Warren Street, Newark, NJ 07102 USA.

^|| To whom correspondence should be addressed. E-mail: Qiufu_Ma{at}dfci.harvard.edu (Q.M.); Charles_Stiles{at}dfci.harvard.edu (C.D.S.)

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EDITORS' CHOICE
DEVELOPMENT
Role of Transcription Factors in Neural Development: (4 January 2005)
Sci. STKE 2005 (265), tw2. [DOI: 10.1126/stke.2652005tw2]
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