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Science 13 August 2004:
Vol. 305. no. 5686, pp. 984 - 986
DOI: 10.1126/science.1100024
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Reports

DNA-Functionalized Nanotube Membranes with Single-Base Mismatch Selectivity

Punit Kohli, C. Chad Harrell, Zehui Cao, Rahela Gasparac, Weihong Tan, Charles R. Martin*

We describe synthetic membranes in which the molecular recognition chemistry used to accomplish selective permeation is DNA hybridization. These membranes contain template-synthesized gold nanotubes with inside diameters of 12 nanometers, and a "transporter" DNA-hairpin molecule is attached to the inside walls of these nanotubes. These DNA-functionalized nanotube membranes selectively recognize and transport the DNA strand that is complementary to the transporter strand, relative to DNA strands that are not complementary to the transporter. Under optimal conditions, single-base mismatch transport selectivity can be obtained.

Department of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, FL 32611–7200, USA.

* To whom correspondence should be addressed. E-mail: crmartin{at}chem.ufl.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A real-time PCR-based method for determining the surface coverage of thiol-capped oligonucleotides bound onto gold nanoparticles..
E.-Y. Kim, J. Stanton, R. A. Vega, K. J. Kunstman, C. A. Mirkin, and S. M. Wolinsky (2006)
Nucleic Acids Res. 34, e54
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Science. ISSN 0036-8075 (print), 1095-9203 (online)