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Science 20 August 2004:
Vol. 305. no. 5687, p. 1124
DOI: 10.1126/science.1098876
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Brevia

Intercontinental Spread of Pyrimethamine-Resistant Malaria

Cally Roper,1* Richard Pearce,1 Shalini Nair,2 Brian Sharp,3 François Nosten,4 Tim Anderson2

Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.

1 London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
2 Southwest Foundation for Biomedical Research, San Antonio, TX, USA.
3 Medical Research Council, Durban, South Africa.
4 Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand.

* To whom correspondence should be addressed. E-mail: cally.roper{at}lshtm.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)