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Research ArticlesThe Wheat VRN2 Gene Is a Flowering Repressor Down-Regulated by Vernalization  
Plants with a winter growth habit flower earlier when exposed for several weeks to cold temperatures, a process called vernalization. We report here the positional cloning of the wheat vernalization gene VRN2, a dominant repressor of flowering that is down-regulated by vernalization. Loss of function of VRN2, whether by natural mutations or deletions, resulted in spring lines, which do not require vernalization to flower. Reduction of the RNA level of VRN2 by RNA interference accelerated the flowering time of transgenic winter-wheat plants by more than a month.
1 Department of Agronomy and Range Science, University of California, Davis, CA 95616, USA.
* These authors contributed equally to this work.
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Present address: Instituto Recursos Biológicos, Instituto Nacional de Tecnologia Agropecuaria, (1712) Castelar, Buenos Aires, Argentina. 
Present address: Consejo Nacional Investigaciones Cientificas y Tecnicas Departamento de Agronomía, Universidad Nacional del Sur, 8000 Bahía Blanca, Argentina. 
To whom correspondence should be addressed. E-mail: 
Science. ISSN 0036-8075 (print), 1095-9203 (online)
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