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Science 14 February 2003:
Vol. 299. no. 5609, pp. 1025 - 1027
DOI: 10.1126/science.1081519
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Perspectives

SIGNAL TRANSDUCTION:
Imposing Specificity on Kinases

Mark Ptashne and Alexander Gann

How does a cell imbue kinase signaling cascades that share some of the same components with a specificity that ensures activation of the correct cellular response? In their Perspective, Ptashne and Gann discuss the leading part played by protein scaffolds and regulated recruitment in conferring specificity on kinase signaling cascades.

M. Ptashne is in the Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. E-mail: m-ptashne{at}ski.mskcc.org A. Gann is at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. E-mail: ganna{at}csh.org

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Science. ISSN 0036-8075 (print), 1095-9203 (online)