Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 July 1999:
Vol. 285. no. 5425, pp. 260 - 263
DOI: 10.1126/science.285.5425.260
Prev | Table of Contents | Next

Reports

BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

Paul A. Moore, Ornella Belvedere, Amy Orr, Krystyna Pieri, David W. LaFleur, Ping Feng, Daniel Soppet, Meghan Charters, Reiner Gentz, David Parmelee, Yuling Li, Olga Galperina, Judith Giri, Viktor Roschke, Bernardetta Nardelli, Jeffrey Carrell, Svetlana Sosnovtseva, Wilbert Greenfield, Steven M. Ruben, Henrik S. Olsen, James Fikes, David M. Hilbert *

The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma . Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.

Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.
*   To whom correspondence should be addressed. E-mail: david_hilbert{at}hgsi.com

Read the Full Text

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)