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Science 26 February 1999:
Vol. 283. no. 5406, pp. 1335 - 1339
DOI: 10.1126/science.283.5406.1335
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Reports

Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry

Kurt Bachmaier, 12 Nikolaus Neu, 3 Luis M. de la Maza, 4 Sukumar Pal, 4 Andrew Hessel, 1 Josef M. Penninger 12*

Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle-specific alpha  myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle-specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle-specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle-specific protein.

1 Amgen Institute, Ontario Cancer Institute,
2 Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario M5G 2C1, Canada.
3 Department of Pediatrics, University of Innsbruck, Medical School, Innsbruck A-6020, Austria.
4 Department of Pathology, University of California, Irvine, CA 92697-4800, USA.
*   To whom correspondence should be addressed. E-mail: jpenning{at}amgen.com

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Science. ISSN 0036-8075 (print), 1095-9203 (online)