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The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58
Derek W. Wood,1Joao C. Setubal,24Rajinder Kaul,5Dave E. Monks,1Joao P. Kitajima,23Vagner K. Okura,2Yang Zhou,5Lishan Chen,1*Gwendolyn E. Wood,1Nalvo F. Almeida Jr.,6Lisa Woo,1Yuching Chen,1Ian T. Paulsen,7Jonathan A. Eisen,7Peter D. Karp,8Donald Bovee Sr.,5Peter Chapman,5James Clendenning,5Glenda Deatherage,5Will Gillet,5Charles Grant,5Tatyana Kutyavin,5Ruth Levy,5Meng-Jin Li,5Erin McClelland,5Anthony Palmieri,5Christopher Raymond,5Gregory Rouse,5Channakhone Saenphimmachak,5Zaining Wu,5Pedro Romero,8David Gordon,9Shiping Zhang,10Heayun Yoo,10Yumin Tao,11Phyllis Biddle,10Mark Jung,10William Krespan,10Michael Perry,10Bill Gordon-Kamm,11Li Liao,10Sun Kim,10Carol Hendrick,11Zuo-Yu Zhao,11Maureen Dolan,10Forrest Chumley,10Scott V. Tingey,10Jean-Francois Tomb,10Milton P. Gordon,12Maynard V. Olson,5Eugene W. Nester113§
The 5.67-megabase genome of the plant pathogen Agrobacterium
tumefaciens C58 consists of a circular chromosome, a linear
chromosome,and two plasmids. Extensive orthology and nucleotide
colinearitybetween the genomes of A. tumefaciens and the
plant symbiont Sinorhizobiummeliloti suggest a recent
evolutionary divergence. Their similaritiesinclude metabolic,
transport, and regulatory systems that promotesurvival in the highly
competitive rhizosphere; differences areapparent in their genome
structure and virulence gene complement.Availability of the A. tumefaciens sequence will facilitate investigationsinto the
molecular basis of pathogenesis and the evolutionarydivergence of
pathogenic and symbiotic lifestyles.
1 Department of Microbiology, University
of Washington, 1959 NE Pacific Street, Box 357242, Seattle, WA 98195, USA.
2 Bioinformatics Laboratory, Institute of
Computing,
3 Center for Molecular Biology and
Genetic Engineering (CBMEG), University of Campinas, CP 6176, Campinas
SP 13083-970, Brazil.
4 Department of Genome
Sciences, University of Washington, Box 357730, Seattle, WA 98195, USA.
5 Genome Center, University of Washington, Fluke
Hall on Mason Road, Box 352145, Seattle, WA 98195, USA.
6 Department of Computing and Statistics, Federal
University of Mato Grosso do Sul, CP 549, Campo Grande MS 79070-900, Brazil.
7 The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
8 Bioinformatics Research Group, SRI International,
333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
9 Howard Hughes Medical Institute, University of
Washington, Box 357730, Seattle, WA 98195, USA.
10 E. I. du Pont de Nemours Company, 1 Innovation Way, Newark, DE 19714, USA.
11 Pioneer
Hi-Bred International Inc., 7300 NW 62nd Avenue, Post Office Box 1004, Johnston, IA 50131, USA.
12 Department of
Biochemistry, University of Washington, 1959 NE Pacific Street,
Seattle, WA 98195, USA.
13 Department of Botany,
University of Washington, 1959 NE Pacific Street, Box 355325, Seattle,
WA 98195, USA.
*
Present address: Department of Pathology, University of
Washington, Box 357470, Seattle, WA 98195, USA.
Present address: Gene Function & Target Validation,
Celltech R&D Inc., Bothell, WA 98021, USA.
Present address: Department of Plant Pathology,
Kansas State University, 113 Waters Hall, Manhattan, KS 66506, USA.
§
To whom correspondence should be addressed. E-mail:
gnester{at}u.washington.edu
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Elizabeth Pennisi (14 December 2001) Science294 (5550), 2266a.
[DOI: 10.1126/science.294.5550.2266a] |Summary »|Full Text »|PDF »
RESEARCH ARTICLES
Brad Goodner, Gregory Hinkle, Stacie Gattung, Nancy Miller, Mary Blanchard, Barbara Qurollo, Barry S. Goldman, Yongwei Cao, Manor Askenazi, Conrad Halling, Lori Mullin, Kathryn Houmiel, Jeffrey Gordon, Mark Vaudin, Oleg Iartchouk, Andrew Epp, Fang Liu, Clifford Wollam, Mike Allinger, Dahlia Doughty, Charlaine Scott, Courtney Lappas, Brian Markelz, Casey Flanagan, Chris Crowell, Jordan Gurson, Caroline Lomo, Carolyn Sear, Graham Strub, Chris Cielo, and Steven Slater (14 December 2001) Science294 (5550), 2323.
[DOI: 10.1126/science.1066803] |Abstract »|Full Text »|PDF »|Supplemental Data »
