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Agrobacterium tumefaciens is a plant pathogen capable of
transferring a defined segment of DNA to a host plant, generatinga
gall tumor. Replacing the transferred tumor-inducing genes withexogenous DNA allows the introduction of any desired gene intothe
plant. Thus, A. tumefaciens has been critical for the
developmentof modern plant genetics and agricultural biotechnology.
Herewe describe the genome of A. tumefaciens strain C58,
which hasan unusual structure consisting of one circular and one
linearchromosome. We discuss genome architecture and evolution and
additionalgenes potentially involved in virulence and metabolic
parasitismof host plants.
1 Department of Biology, Hiram College, Hiram,
OH 44234, USA.
2 Department of Biology, University
of Richmond, Richmond, VA 23173, USA.
3 Cereon
Genomics, LLC, 45 Sidney Street, Cambridge, MA 02139, USA.
4 Monsanto Company, 800 North Lindbergh Boulevard,
St. Louis, MO 63167, USA.
*
To whom correspondence should be addressed. E-mail:
steven.c.slater{at}cereon.com
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[DOI: 10.1126/science.294.5550.2266a] |Summary »|Full Text »|PDF »
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Derek W. Wood, Joao C. Setubal, Rajinder Kaul, Dave E. Monks, Joao P. Kitajima, Vagner K. Okura, Yang Zhou, Lishan Chen, Gwendolyn E. Wood, Nalvo F. Almeida, Jr., Lisa Woo, Yuching Chen, Ian T. Paulsen, Jonathan A. Eisen, Peter D. Karp, Donald Bovee, Sr., Peter Chapman, James Clendenning, Glenda Deatherage, Will Gillet, Charles Grant, Tatyana Kutyavin, Ruth Levy, Meng-Jin Li, Erin McClelland, Anthony Palmieri, Christopher Raymond, Gregory Rouse, Channakhone Saenphimmachak, Zaining Wu, Pedro Romero, David Gordon, Shiping Zhang, Heayun Yoo, Yumin Tao, Phyllis Biddle, Mark Jung, William Krespan, Michael Perry, Bill Gordon-Kamm, Li Liao, Sun Kim, Carol Hendrick, Zuo-Yu Zhao, Maureen Dolan, Forrest Chumley, Scott V. Tingey, Jean-Francois Tomb, Milton P. Gordon, Maynard V. Olson, and Eugene W. Nester (14 December 2001) Science294 (5550), 2317.
[DOI: 10.1126/science.1066804] |Abstract »|Full Text »|PDF »|Supplemental Data »
